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The long half-life is achieved through fatty acid conjugation, similar in strategy to semaglutide
The oral route of administration for GLP-1 does pose challenges due to the drugs high molecular weight, extremely low absorption with the commercially available oral tablets, and the drugs sensitivity to the heat required to compound it into a lozenge
Heine, M
Effect of GLY-HIS-LYS and its copper complex on TGF- secretion in normal human dermal fibroblasts
How is the gut functioning
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