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Notably, only four patients of pNC were observed in the IGL group, whereas the majority were in the IGH group (Fig
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The outcome was very promising as measured by a higher response rate and significant reduction score on the scale of assessment of positive symptoms
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Consequently, pro-caspase-1 self-cleavage produces the activated caspase-1, which in turn cleaves gasdermin-D (GSDMD), and the N-terminal GSDMD fragments finally form pores into the plasma membrane through which inflammatory mediators are released, among which IL-1 and IL-18 (Franchi et al., 2009
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