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As per Bradford Hills criteria 41 , the biological plausibility through GLP-1R expression in the nervous system and temporal consistency in time-to-onset analysis support potential causality, but confounding factors inherent to spontaneous reporting systems preclude definitive conclusions
With the advancement of multi-omics sequencing technologies, including proteomics, transcriptomics, and metabolomics, alongside genetic code extension and machine learning, the mapping of lactylation networks, including lactylated proteins, specific modification sites, and protein function in various physiologies and pathologies, is anticipated to be elucidated more comprehensively
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Amylin receptor agonism and metabolic regulation
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