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For quantification of sulfur-containing metabolites in cultured cancer cells and mouse serum, 10 l samples were extracted with 90 l of ice-cold extraction solvent (80% methanol and 20% H 2 O) containing isotope-labelled internal standards (36 M 13 C 2 15 N-GSH, 0.92 M 13 C 4 15 N 2 -GSSG and 10 M D 4 -cystine)

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If desire and distress scores do not improve, the provider may recommend a different approach

For these individuals, medications such as Mounjaro or Wegovy may be more effective when used as part of a long-term management strategy rather than a defined short course

83 PengC.FuX.WangK.ChenL.LuoB.HuangN.et al (2022)