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Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, et al

PMID 28629176

For a deeper guide, you can also read about eating on GLP-1 with tiny appetite

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The effects of dual GLP-1/GIP receptor agonism on glucagon secretion: a review

But if you would then extend that half life to a day, or now seven days a week, that slowing in the gut motility is what we think is behind this sense of fullness, and possibly some of the nausea that people experience, and in the longer term, constipation, because your gut motility is a little bit slower. More seriously, though, GLP-1 therapy is thought to sometimes cause too much slowed digestion, which can result in a condition called gastroparesis