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Pros: Legal with a prescription, medical oversight from prescriber, more predictable quality than grey market Cons: Expensive ($200$500/month), not FDA-regulated, insurance doesn't cover it, legal status uncertain Cost details: See our retatrutide cost guide 3
None of that makes this an easy yes or no
A widely cited extension of the STEP 1 trial found that participants who stopped semaglutide regained roughly two-thirds of their weight loss within a year
The study included participants taking semaglutide, tirzepatide and liraglutide
The same study confirmed dose-dependent increases in GH without significant changes in other pituitary hormones (prolactin, TSH, LH, FSH, cortisol), supporting its selectivity for the GH axis
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