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MAP kinase signalling pathways in cancer
This effect was seen in both human intestinal and immune cells, as well as in mice with experimentally induced colitis, showing that taking KPV by mouth can reduce inflammation in the gut
In diabetic nephropathy, depletion of endogenous polyamines contributes to podocyte injury, whereas exogenous spermine restores podocyte integrity by activating autophagy via the AMPKmTOR pathway, reducing apoptosis and glomerular damage 120
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