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In the Semaglutide (10 nmol/kg) group, non-fasting blood glucose levels began to decrease at 0.5 hours after administration and remained reduced until 24 hours

Importantly, the upregulating effects of metformin on GLP-1R level and PKA phosphorylation were eliminated by adding AMPK inhibitor compound C

GLP-1 plays a crucial role in regulating several physiological and metabolic functions, including appetite, satiety, glucose and insulin balance, GI motility, liver fat metabolism, and even bone remodeling (1)

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