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Urgency, the sudden intense need to urinate that feels difficult to delay
Efficacy vs
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Sulfonylureas stimulate glucose uptake through GLUT4 transporter translocation in rat skeletal muscle
Continuous use beyond 6 weeks leads to IGF-1 receptor downregulation (decreased density and sensitivity)
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Most often the functional nomenclature for renal transporters can be a bit confusing as well since a common theme is to indicate a transporter present on the basolateral (blood side) membrane is functioning as secretion transporter while a transporter found in the apical (luminal side) membrane is functioning as an uptake or reabsorption transporter
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