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The intestinal microbiome exhibits its own daily rhythmicity in composition and function, which is entrained by feeding cycles
Thus the increased glutamate flux through GDH generates KG while sparing keto acid consumption (reduced transamination)
Foundational mouse study (Baar et al., 2017, Cell) Designed FOXO4-DRI and showed selective senescent-cell clearance, with restored fitness, fur density, and kidney function in aged and chemotherapy-treated mice
Exons 11 and 12 encode the antenna-like domain, which is located at the pivot helix of the GDH structure and adjacent to the GTP allosteric binding domain encoded by exons 6 and 7
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