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The selectivity arises from the peptides structure representing only the lipolytic region of growth hormone without the receptor-binding domains responsible for broader effects
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The complexity of their action requires careful dose titration and monitoring to avoid adverse effects such as hypoglycemia
In a retrospective study completed by Nadeem et al., it was shown that GLP-1 RAs are associated with an overall fourfold increase in the retention of gastric contents in both diabetic and non-diabetic patients ( p -value 0.8 mL/kg of gastric fluid content (measured from the aspiration/suction canister)
Nauck MA, Homberger E, Siegel EG et al (1986) Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
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