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Some authors have supported the presence of GLP-1 receptors on the hepatocytes [54], while others do not [55]
Gileads sofosbuvir polymorph patents were challenged on exactly this basis by I-MAK in 2017, with the challengers arguing that the beta crystalline form protected by key sofosbuvir secondary patents was a predictable discovery for a skilled formulation chemist not an inventive step warranting patent protection through 2034
(2) Ipratropium acts as a competitive antagonist at muscarinic receptors in bronchial smooth muscle, inhibiting acetylcholine binding and blocking parasympathetic-mediated bronchoconstriction
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The mainstay therapy for aplastic anemia includes immunosuppressants such as cyclosporine
doi: 10.17179/excli2019-1447
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