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They should be started at the lowest dose because they can have GI side effects like nausea, vomiting, diarrhea, and constipation

Wang, X.-X

During a direct drug challenge, the medication is given as one single dose or multiple, gradually increasing doses under supervision in the allergist's office

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Over what timeframe does the article say its weight-loss figures were measured

A 3-D network of crosslinked polymeric nanogel allows efficient encapsulation of diverse drug types, promoting flexibility in treatment approaches for various diseases