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Li GF, Zhao M, Zhao T, Cheng X, Fan M, Zhu LL (2019) Effects of metformin on depressive behavior in chronic stress rats

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The molecular responses observed vary according to receptor subtype, peptide concentration, exposure time, cell model, and overall study design, and MTII is employed to characterise melanocortinreceptor signalling rather than to infer defined biological or physiological effects

Yes, both aerobic exercise (brisk walking, cycling, swimming) and resistance training may enhance GLP-1 secretion and improve insulin sensitivity