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Questions and Answers: Semaglutide and Fast Heart Rate Semaglutide has been associated with increased heart rate in some patients

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This makes dosing errors more likely than with commercially manufactured drugs

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Always use new sterile syringes for each injection Dispose of needles using a proper sharps container Rotate injection sites to reduce irritation Inject slowly to minimize leakage Keep a research log of dosing and timing GLP-1 interacts with GLP-1 receptors located in pancreatic beta cells, gastrointestinal tissues, and regions of the central nervous system involved in appetite signaling