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In humans, no allicin has been detected in the serum or urine up to 24 hours after the ingestion of 25 g of raw garlic containing a significant amount of allicin (8)

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However, the rate of improvement slowed the largest changes occurred between weeks 4-8, with weeks 8-12 representing diminishing marginal gains

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The evidence base includes early pharmacology, animal research, a small healthy-volunteer PK/PD study, and a controlled phase 2 postoperative-ileus trial

Vegans and vegetarians may have lower baseline levels due to reduced dietary intake, though clinical deficiency in otherwise healthy individuals remains uncommon