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In a more recent multicenter, randomized, double-blind, placebo-controlled study, supplemental vitamin E (2,000 IU/day

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Data on alcohol consumption at peri-conception are however scarce from those studies (James et al., 1999), and this is another factor that could interfere with one-carbon metabolism, as well as smoking habits or information on other micronutrients, such as for example zinc which may affect the activities of enzymes such as BHMT and MTR (Santos-Rebouas et al., 2008

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Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways