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It is an unapproved investigational compound that did not complete clinical development, has not been authorized by Health Canada for any human or veterinary indication, and is not intended to diagnose, treat, cure, or prevent any disease
Sean Wharton, leader of the Wharton Medical Clinic for Weight and Diabetes Management in Ontario, Canada.Researchers tested the triple-dose of semaglutide in two clinical trials, one involving people with obesity and the other in people with obesity and type 2 diabetes.In both trials, participants were randomly assigned to receive either placebo injections or injections of 2.4 mg or 7.4 mg of semaglutide for 72 weeks.In adults without diabetes, a 7.2 mg dose of semaglutide caused an average weight loss of nearly 19%, surpassing the 16% seen with the 2.4 mg dose and 4% with placebo.Nearly half of the people on the higher dose lost 20% or more of their body weight, with one-third losing at least 25%, researchers reported.Adults with type 2 diabetes had similar results 13% weight loss on the heavier dose versus 10% on the lighter dose and 4% with placebo.Participants on the higher dose also achieved trimmer waistlines and lower blood pressure, blood sugar and cholesterol, results showed.Both trials also reported that the higher dose of semaglutide was safe and generally well tolerated
338 Multiple controlled clinical trials and meta-analyses have shown saffron extract, typically at a dose of 30 mg per day, is more effective than placebo and comparable to antidepressant drugs for improving mild-to-moderate depression
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