Therefore, the SGLT2-i induced elevated ANG II levels could act through AT2R resulting in vasodilation, sodium excretion, antiproliferative and anti-inflammation effects ( In addition, it has also been observed a SGLT2-i induced ACE2/ANG(1-7) pathway activation that may play a role in cardioprotection by competing with ANG II and AT1R ( Furthermore, the SGLT2-i hybrid diuretic effect, which combines natriuresis and osmotic diuresis, might also have cardioprotective properties leading to preload and myocardial stretch reduction (the diuretic hypothesis) ( Therefore, SGLT2-i diuretic properties show a major advantage compared to thiazides and thiazides-like diuretics, which act on the Na + CL - -cotransporter in the distal convoluted tubule, or loop diuretics, which block the Na-K-2Cl co-transporter of both the Henle loop and the macula densa, making the macula insensitive to the increased tubular sodium coming from the Henle loop
Proper hydration can also help maintain skin elasticity and muscle firmness, which may improve the appearance of sagging after weight loss
HUBERMAN: It does have certain advantages, in particular that it increases growth hormone release by two mechanisms
Figures reproduced from Wikipedia Commons (Mikael Hggstrm)
High blood pressure in your liver can also damage blood vessels in your kidneys
Consistent glutathione supplementation coupled with hormone therapies ensures harmonious function of the bodys systems for optimal health outcomes
