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They include high drug costs, unpleasant gastrointestinal side effects, poor insurance coverage and drug shortages
The key practical difference in tolerability: tirzepatides GIP component may partially offset some GI effects of GLP-1 agonism through GIPs effect on gastric motility which may explain why some patients who discontinue semaglutide due to GI side effects tolerate tirzepatide better, though this is not consistently demonstrated across all patients
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