Following dichotomization of ALT responders based on a median 12.9% decrease from baseline, we found that ALT responders were younger in age and did not have severe diabetes compared with ALT non-responders
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This mechanism contributes significantly to weight loss, which is why medications such as semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda) have gained approval for weight management in addition to diabetes treatment
Liver enzymes (AST, ALT, amylase, lipase) showed no consistent clinically important elevations in pooled data
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