In vitro , selenium atoms scavenge ROS in macrophage mitochondria, inhibit osteoclast differentiation and function, and suppress early chondrocyte apoptosis to maintain equilibrium between cartilage matrix synthesis and degradation
The induction of cytotoxicity by H 2 O 2 is a widely adopted approach to explore the potential neuroprotective and antioxidant effects of natural products 39
In contrast, increased status of cellular H 2 O 2 (or exogenous H 2 O 2 ) can increase Pro level by modulating the ex-novo synthesis of Pro (Matysik et al., 2002)
Also, to assess the AES symptoms, items from a previously established questionnaire available in the cohort were utilized, following theoretical models and earlier research findings
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