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In human cell culture studies, increased expressions of PAI-1 and VCAM-1 have been reported to be associated with hyperglycemia-related endothelial cell dysfunction, a process that predisposes vasculature to accelerated atherogenesis 52
Despite shorter duration, oral semaglutide can still produce meaningful weight loss when taken consistently each day, as sustained daily intake maintains therapeutic blood levels
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This is to prevent possible desensitization to the peptide, which can occur with continuous use
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