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The ROS generation was detected with a Leica fluorescence microscope (Leica DM6000B) using Leica LAS X software, and quantitative analysis was performed with ImageJ software (version 1.60

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Given the limited regenerative capacity of neurons, sustained disruption of proteostasis progressively overwhelms cellular quality control systems, leading to synaptic dysfunction, neurodegeneration and irreversible cognitive or motor decline

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ALA has been shown to increase cellular levels of glutathione and protect against oxidative stress

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Plasma riboflavin, as well as riboflavin intake, is positively associated with 3-hydroxyanthranilic acid and xanthurenic acid (73)

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FDA GRAS determination (2007): The FDA reviewed AOD-9604's toxicology data and granted Generally Recognized As Safe status for oral use as a food ingredient

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