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Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): A randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial
Current Opinion in Cardiology, 23(3), 258262.
Presented for research literature review only Sekine Y et al
A more individualized response-based approach monitors body composition changes and continues therapy as long as positive progress occurs, adjusting or pausing when plateaus develop or goals are achieved
There are no studies that support microdosing as a method to maintain weight loss
Authors perspective and future directions Current evidence supports SGLT2 inhibitors as a core component of contemporary heart failure management because of their consistent reductions in HF hospitalization and cardiovascular death across a broad range of patient populations [8,9,10,11,12,13, 45, 49]
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