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Because this combination is not approved yet, healthcare providers will eventually closely monitor patients for gastrointestinal side effects, such as nausea, vomiting, or constipation, and adjust doses accordingly to maximize benefits while minimizing discomfort

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A combined treatment yielded no additive effect, indicating PMPs independent action (Supplementary Fig

560 droxidopa, a norepinephrine precursor that enhances sympathetic tone by increasing norepinephrine levels and improving orthostatic symptoms