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Metformin's long track record of safety and tolerability across decades makes it a stable foundation, while GLP-1 medications add weight loss benefits and cardiovascular protective effects recognized in major trials
Mar 26;3(3):CD009374
Acid reflux, also known as gastroesophageal reflux disease (GERD), occurs when stomach acid flows back into your esophagus
Some research points to possible anti-inflammatory benefits, although this is still being studied
Following -adrenergic stimulation of WAT, PKA phosphorylates perilipin-1 at multiple sites resulting in the release of ABHD5 which in turn, binds to and stimulates ATGL
More serious but less common adverse effects include pancreatitis, gallbladder disease (cholecystitis and cholelithiasis), and acute kidney injury, particularly in the setting of severe dehydration from gastrointestinal symptoms
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