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Cardiovascular Outcomes# LEADER Trial (Liraglutide)# The LEADER trial (Marso et al., NEJM 2016) enrolled 9,340 patients with type 2 diabetes and high cardiovascular risk
Improved Metabolism: By positively influencing blood sugar levels and insulin sensitivity, it aids in better calorie processing
Semaglutide activates GLP-1 receptors in your brain and gut within hours of injection, triggering reduced hunger signals and slower stomach emptying
The distribution of protein intake across the day is as important as total daily amount for optimizing muscle protein synthesis and preservation during GLP-1 therapy
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/profile/Asfandyar-Sheikh/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)