Insert the needle quickly yet controlled at a 90-degree angle into the injection site
Extended titration, dietary changes, and timing adjustments are all proven approaches that should be exhausted before moving to experimental modifications
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Cardio- and reno-protective effects are unlikely to be solely explained by the mechanisms used by these drugs to lower blood glucose levels, as the same effects are not seen with drugs that have stronger antihyperglycaemic actions [111], and were not dependent upon the degree of HbA1c reduction [113,114,115]