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This extracellular protein is then packaged into tumor-derived exosomes and is absorbed by macrophages, leading to the switch from the M1 phenotype to the M2 phenotype and accelerating cancer progression (Gan et al., 2021)

10.1155/2019/9084643 67 KraljT.KokotA.KasnikK.DrmicD.ZlatarM.SeiwerthS.et al (2017)

A notable example includes the co-delivery of resveratrol and paclitaxel via PEGylated liposomes, which exhibited potent cytotoxicity against drug-resistant breast cancer cells (MCF-7/Adr) in vitro and enhanced tumor retention in vivo without increasing systemic toxicity

Additionally, metformin can improve endometrial receptivity by increasing the expression of GLUT4 in the endometrium, regulating the expression of hormone receptors related to endometrial decidualization, and modulating autophagy and nucleic acid/protein transcription processes, which in turn improves the reproductive outcomes of PCOS

Leytus SP, Loeb KR, Hagen FS, Kurachi K, Davie EW

Together, our data suggest that there is significant cross talk between the injured kidney and the liver during ischemic AKI