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For severe cases, the first dose is usually 1,000 mcg given intramuscularly every day or every other day for a week or two

This may explain some of its protective effects on various tissues

Genetic variants in B12 metabolism pathways (e.g., MTHFR, MTR, MTRR genes) can influence how efficiently your body processes and utilizes B12, potentially affecting both side-effect risk and clinical benefit

Regular doses of Vitamin B12 are recommended to see the best results as our bodies do not store this vitamin for very long

Presented for research literature review only Yang CM et al