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Because of this short half-life, most clinical protocols call for daily dosing or, in some cases, twice-daily dosing to maintain consistent levels in the body throughout the treatment period
The IV is a longer reset
Assessment of Grx1 system activity in vitro Grx activity assessment is based on the method of Coppo et al
NADPH is generated through several pathways, such as the pentose phosphate pathway (PPP), NADK-catalyzed NADH phosphorylation, and IDH-catalyzed conversion of isocitrate to -KG
1998, doi: 10.1359/jbmr.1998.13.7.1158
Gahl WA, Dalakas MC, Charnas L, Chen KT, Pezeshkpour GH, Kuwabara T, Davis SL, Chesney RW, Fink J, Hutchison HT (1988) Myopathy and cystine storage in muscles in a patient with nephropathic cystinosis
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