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Five-day dosing at any given milligram amount would produce effective drug exposure comparable to a higher milligram dose at weekly intervals
[24] [25] Individuals with MEN 2 carry germline RET mutations conferring near-100% lifetime risk of developing MTC, often presenting in childhood or early adulthood
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What remains unknown Despite encouraging data, genuine unknowns exist: Effects beyond 6-9 months of continuous use have not been formally studied in animals or humans
2022 , e202101481 (2022)
It is possible that the placebo effect may be enhanced in our study due to the shared decision-making process, whereby patients receive lifestyle advice and increased attention from their treating clinician, which may result in favourable behavioural changes [48]
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