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Such a strategy has been demonstrated in the case of cholangiocarcinoma, where IDH1 mutations resulted in the production of the oncometabolite 2-hydroxyglutarate, leading to epigenetic alterations and changes in the expression of key genes involved in cell differentiation and survival [202]
doi: 10.1186/s13098-024-01301-3
10.1186/1465-9921-12-41 125 PeiM
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10.1073/pnas.1811974115 148 LeidalA
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