Svensson J, Ohlsson C, Jansson JO, Murphy G, Wyss D, Krupa D, Cerchio K, Polvino W, Gertz B, Baylink D, Mohan S, Bengtsson BA
Promote renal calcium reabsorption Renal tubular calcium transport: upregulate the expression of renal tubular calcium channel (TRPV5), reduce urinary calcium excretion by 30% -40%, increase blood calcium concentration, and increase bone calcium deposition Evidence from preclinical studies on AOD 9604 bone protection (animal experiments) Postmenopausal osteoporosis (OVX rat model) Experimental Design: Animal: 6-month-old female SD rats underwent bilateral ovariectomy (OVX) to establish a postmenopausal osteoporosis model
doi: 10.1007/s40265-022-01746-8 55 KaragiannisTAvgerinosILiakosADel PratoSMatthewsDRTsapasA
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Two studies were conducted to assess the effects of renal or hepatic impairment on pharmacokinetics, safety and tolerability following single doses of cagrilintide
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