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Choi notes that an important factor in each person's response is the number of weight-loss cycles they've experienced throughout their lifetime

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However, the magnitude of some of these observational estimates (for example, relative reductions in cardiovascular or all-cause mortality exceeding 50%) is considerably larger than would be predicted from the randomized effect sizes of either class and is almost certainly inflated by residual and time-related confounding, including healthy-adherer and prevalent-user biases

But I do think an important element is getting overlooked: In both cases, the designation as a disease aligns uncomfortably close with commercial incentives, crowding out discussion of the conditions social, psychological, and economic dimensions

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En casos clnicos, se ha utilizado como apoyo en la recuperacin tras infartos de miocardio, por su efecto en la funcin mitocondrial del msculo cardaco