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These computational findings are consistent with experimental and preliminary clinical evidence, including observational studies and randomized clinical trials, suggesting that metformin may reduce the risk of AD and comorbid AD in individuals with DM2 while also enhancing cognitive performance 52,53,54,55,56,57

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Head-to-head trials (CONCLUDE and BRIGHT) showed comparable glucose control between the two, with some differences in hypoglycemia patterns depending on the trial design

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