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PMID 31780780
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It exhibits an IC 50 of approximately 1 M for NNMT inhibition 4 , with favorable pharmacokinetic properties
Conditions like pernicious anaemia (an autoimmune condition affecting a protein called intrinsic factor vital for B12 absorption), stomach issues (such as from reduced stomach acid or certain medications like proton pump inhibitors), intestinal disorders (like Crohns disease or coeliac disease), or even surgical removal of parts of the small intestine (e.g., gastric bypass surgery) can prevent proper absorption
In a study in old mice, NNMT inhibition was shown to promote stem cell activation following injury
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