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Bown et al similarly showed strong predictive effects of baseline arterial stiffness on occipital and hippocampal volume and temporal lobe white matter hyperintensity volume in a 5-year follow up (Bown et al., 2021), all of which are brain regions that are highly vulnerable to neurodegeneration (Fjell et al., 2014)
Uhlen M, et al
Therefore, we speculated that DMF could affect 2OG or 2HG levels to affect DNA methylation and revisited the initial LC-MS analyses which showed there are significantly reduced levels of 2HG, but not 2OG after DMF treatment (Fig
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