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Deficiency of B12 predominantly affects hematological and neurological systems, although neuropsychiatric symptoms are often the first clinical manifestation

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Novo leadership pointed to the open-label design as a source of bias, suggesting that investigators, many of whom were already familiar and comfortable with Tirzepatide, may have pushed patients more aggressively on the Lilly arm

Only increase if lower doses plateau and you tolerate well

10.1016/j.cell.2013.01.055 Cell 193 ZeeP

Coordination problems increase the risk of falls and injuries, further impacting quality of life