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Oxidative stress can be caused by elevated levels of sugar in the blood (hyperglycemia), as well as insulin deficiency or resistance
The copper(II) ion in GHK-Cu is a cofactor for lysyl oxidase (LOX), the enzyme responsible for collagen and elastin cross-linking in blood vessel walls
The tyrosine-derived fragment contributes an aromatic phenolic ring system, while the isoleucine-derived segment introduces a branched aliphatic side chain
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