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Week 21 and beyond: Discontinue
2013 May
In mice treated for 4 weeks with SLU-PP-332 (Billon 2023, 10-30 mg/kg orally or IP): - Skeletal muscle : increased mitochondrial content (mitochondrial/nuclear DNA +30-50%), slow-oxidative fiber shift, increased beta-oxidation enzymatic capacity, treadmill endurance increase +45 to +70%
Additional gel packs
Instruct patients of the risk of rapid hyperglycemia and ketosis due to pump malfunction, infusion set occlusion, leakage, disconnection or kinking, and degraded insulin
GLP-1 is released in the gut in the presence of glucose and stimulates the release of insulin from pancreatic B cells, enabling fine control of blood sugar levels
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