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xCT deficiency induces autophagy via endoplasmic reticulum stress activated p38-mitogen-activated protein kinase and mTOR in sut melanocytes

Physician Sportsmed 12(10):97106 van der Worp H, Zwerver J, Kuijer PP, Frings-Dresen MH, van den Akker-Scheek I (2011) The impact of physically demanding work of basketball and volleyball players on the risk for patellar tendinopathy and on work limitations

Glucuronidation (50-60%) - SAFE Primary detoxification pathway in adults Makes acetaminophen water-soluble for excretion INCREASES during pregnancy but cannot compensate for other pathway changes Severely underdeveloped in fetuses/newborns 2

They work together in a cycle for maximum free radical defense