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GLP-1R agonists reduce food intake by triggering both aversive or emetic neural and satiety signals which are dissociable in rodents (7376)
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Both medications improve glucose control, but tirzepatides dual mechanism may offer additional benefits for patients with insulin resistance or prediabetes Budget considerations
Curigliano, G
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Glucagon also contributes to energy homeostasis by promoting satiety through vagal signaling to brainstem nuclei and by increasing resting energy expenditure through facultative thermogenesis in brown adipose tissue, skeletal muscle, and through promotion of WAT browning [22]
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