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Patients with diabetes already face a higher risk of atrial fibrillation, so understanding how these GLP-1 receptor agonists affect cardiac electrophysiology is essential

Valproic acid, which has been used as an antiepileptic drug for many years and still is used in this indication, has been shown to inhibit preferably class I HDACs in the high micromolar to millimolar range

Breastfeeding or pregnant female

Health authorities consider it an unapproved drug

Patients experiencing significant gastrointestinal symptoms may also reduce food and fluid intake, compounding the problem