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However, no clinical trials validate efficacy in humans

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Combining them is meant to recruit the amylin pathway on top of the GLP-1 pathway, and the two were formally co-administered and tested together as CagriSema. [4] For the amylin side of that equation, our references on how cagrilintide affects gastric emptying and post-prandial metabolism and how cagrilintide influences brain satiety circuits go deeper into the mechanism

Underhill SM, Wheeler DS, Amara SG (2015) Differential regulation of two isoforms of the glial glutamate transporter EAAT2 by DLG1 and CaMKII

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