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Motility issues are a known factor in developing SIBO
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The in vivo HITI-mediated knock-in efficiency at the Alb locus in this study is comparable to that of other knock-in methods, such as HDR (~2%) and NHEJ (~2%) 33,34
Neither medicine is always better than the other
Our work provides an alternative strategy by combining dual-path synthesis with energy metabolism regulation and precursor feeding to improve GSH production
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