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The peptide has been studied across more than 100 peer-reviewed publications, with significant bodies of work published in the Journal of Pharmacological Sciences, Life Sciences, Journal of Physiology and Pharmacology, and Current Pharmaceutical Design
5 However, caution is warranted on consuming these large doses, as excess intake can cause toxicity
Molecules (2014) Stable gastric pentadecapeptide BPC 157 in trials for inflam
The Kraus 2014 Nature Paper: Why Adipose Research Specifically The 2014 Nature paper by Kraus and colleagues (titled "Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity") established the adipose-NNMT connection that anchors all subsequent NNMT-inhibition research in fat biology
The safest current interpretation is that methylation-related concerns are biologically plausible and relevant to study design, but they are not established as consistent toxicological findings for 5-Amino-1MQ under all published preclinical conditions
Additionally, B12 works alongside folate (vitamin B9) in the production of red blood cells and supports homocysteine metabolism
