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Differences were evaluated by Students t test for two groups, one-way analysis of variance for multiple groups, and parametric generalized linear model with random effects for tumor growth

The lack of any significant difference in GSIS was surprising, as we had expected that, because of their Nnt WT expression, N5-WT islets would have a greater GSIS, as do BL/6N islets

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In addition, in vitro studies have shown that recombinant TTR amyloid aggregates are internalized by human cardiac fibroblasts, which subsequently secrete IL-6 and IL-8, providing mechanistic evidence that TTR aggregates can trigger inflammatory responses in cardiac cells [77]