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7 In pancreatic -cells, GLP-1R activation by semaglutide enhances glucose catabolism and insulin secretion via the mTOR-dependent HIF-1 pathway, facilitating glycolysis and insulin release
The combined activation of these three pathways is being investigated for additive or synergistic effects across metabolic research
Importantly, these reductions were solely driven by reductions in macroalbuminuria without effects on hard renal endpoints
However, in the absence of data on peoples underlying medical risk factors, it is not possible to understand the extent to which this reflects true medical need, e.g
Statistical significance was estimated using Students t-test or the analysis of variance followed by Bonferronis t-test as described in the legends
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